Very much so.
Ni80 or nichrome heats up much quicker than kanthal hence a lot of mech mod users prefer it. I use it too but it's a different animal to kanthal.
The idea behind coiling, for me anyway, is to get as much surface area as possible to vapourise as much juice as possible at any one time. Claptons and the like are designed to heat up the outer, smaller wire first which in turn heats up the inner wire quicker. If you were to use a round wire and Clapton build with both the same diameter then the Clapton would have much less ramp up time.
The Buddha is very, very airy. As long as your airflow holes are aligned with that you should be good. The post screws don't usually back out either, but check your resistance once you've fired and pinched, then again one you've wicked and again when you're juiced. Check the post screws at these points too, then again when you re wick. It could be a short or a nick in the wire too.
Nichrome and the way it behaves is a little more adavanced than kanthal. If I were you I'd fire for a 6/7 wrap of your kanthal wire on each side and get that working well before you play with the nichrome as your resistance will be much lower too if it's nichrome wire. That's why I use it- I can, for example, do an 8 wrap nichrome and get the same resistance as I would a 5 wrap kanthal. Thus increasing my surface area and staying at the kind of resistance I want it to be at.
Keep experimenting, shoot for around a 0.5 resistance once both coils are in place and see how you go.