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interesting paper on nicotine

Discussion in 'In The News' started by dahut, Sep 11, 2018.

  1. dahut

    dahut Achiever

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    enjoy guys
    "We propose that e-cig users (vapers) achieve measurable serum nicotine levels when they inhale nicotine and nicotyrine together, because nicotyrine reversibly inhibits nicotine metabolism by CYP2A13 in airways. Consuming nicotyrine by any route should irreversibly inhibit hepatic CYP2A6. When CYP2A6 is substantially inhibited, nicotine clearance is delayed and nicotine withdrawal symptoms are attenuated. Small, relatively infrequent nicotine doses can then sustain satisfying nicotine levels."
    https://www.sciencedirect.com/science/article/pii/S0306987715002212
     
  2. Quahog5

    Quahog5 Postman

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    Cheers...I think. If anyone could explain this report in plain English that’d be great, going for a lie down now
     
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  3. dahut

    dahut Achiever

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    from what i read u need some oxidised nicotine to help the nicotine be absorbed probably into the body ,
    without nicotyrine -oxidized nicotine- u cant absorb as much nicotine ??

    copy from link-
    "nicotyrine is not an incidental contaminant, but an important component in many e-cig aerosols that successfully deliver nicotine to users. To achieve a satisfying serum nicotine level in vapers with normal CYP2A13 activity, e-cigs must do at least one of the following: (1) aerosolize partially oxidized e-liquids; (2) oxidize some nicotine in the process of aerosolization; (3) "
     
    #3 dahut, Sep 11, 2018
    Last edited: Sep 11, 2018
  4. dahut

    dahut Achiever

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    any scientists or anyone with a iq higher than mine ie 20+ could shed some light here i would be greatfull :D
     
  5. JesusFoggingChrist

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    So basically its like putting a chem like sponge in yourself to soak up the nic better?...
     
  6. dahut

    dahut Achiever

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    seems Reddits always one step ahead
    click .img for link

     
  7. dahut

    dahut Achiever

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    it stops the body from producing something that inhibits the body metabolising nic in airways
    so yes in lay mans terms seems so
    amazing read



    now pondering on my whole diy routine :hmm:

    nicotine base premade a month or two in advance and perhaps aired to promote a slight oxidization of the nicotine seems the way forward
     
    #7 dahut, Sep 12, 2018
    Last edited: Sep 15, 2018 at 6:00 PM
  8. Ment

    Ment Legend

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    In simple terms, nicotyrine prevents the break down of nicotine, meaning it stays in your body longer, reducing the amount you need to vape.
     
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