Anytime a mesh is not right, check for hot spots. Just because you spent ages getting rid of them, does not mean they are not back a minute later. I only ever managed one good mesh build, fortunately it was my first and I used it for months. I have spent a couple of weekends trying to repeat that early beginners luck. Perhaps one day I will return to genesis and mesh, I really liked it but @Jugg1es did warn you, read his post again I think he said it all.